Family Supper focuses on the artist's family, and particularly on his mother, Ginevra. Shown in their Sullivan Street apartment, the members of the family are gathered around a table set with fruit, espresso and Italian pastries. Ginevra Fasanella is shown seated at the head of the table, clothed in a white robe of purity. She is a vision of the gentle, nurturing spirit of the family, to whom the others cling for spiritual and emotional sustenance. Fasanella memorializes his mother's sacrifices by placing her on a cross directly above the family group. His father appears as an illustration on a calendar on the wall at the right. The remainder of the canvas is an encyclopedia of the familiar, including a gas meter which dispenses light for a quarter, a flour sack used as a dish towel, an old Singer sewing machine, a trunk from Italy and numerous other details that show the artist's intimate knowledge of tenement life.

For those with working-class roots, the remainder of the canvas is an encyclopedia of the familiar. Fasanella includes a gas meter that dispenses light for a quarter, a flour sack used as a dish towel, an old Singer sewing machine, a trunk from Italy, and numerous other details that show his intimate knowledge of tenement life.